As a firm believer in alternative medicine – and being the passionate person I am when it comes to combining a healthy diet with an active lifestyle – one of the most important things I take into consideration is what I put into my body. Living in today’s fast-paced environment isn’t always an easy task, and it can often lead to complications such as stress, pain and anxiety – just some of the “mild” conditions that modern society is experiencing an increased prevalence of. Unfortunately, some people have to live with much worse. If you suffer from a medical condition and are absolutely fed up with the increasing barrage of prescription drugs that our doctors are handing out, or if you are simply looking for some relief, then this article is for you. CBD has been shown to help treat a variety of conditions such as anxiety, depression, and pain, and it has even been used to help with more serious ailments like arthritis and opioid addiction. There have been research studies linking significant health benefits of CBD to dozens of medical conditions. Whether you are totally new to CBD or are simply looking for a high-grade, best CBD oil brand, see who ranked top on my list. Also don’t forget to check out number one!
Sativex may interact with alcohol, affecting coordination, concentration, and ability to respond quickly. In general, alcoholic beverages should be avoided whilst using Sativex, especially at the beginning of treatment or when changing the dose. Patients should be advised that if they do drink alcohol while using Sativex the additive CNS effects may impair their ability to drive or use machines, and increase the risk of falls.
The color of CBD oil drops can range from clear or slightly golden, to a dark brown almost black. Several factors determine the finished product color, including the type of CBD extract, the extraction method used, the carrier oil used, and additional ingredients. Full spectrum (whole plant) extracts tend to be darker in color, whereas isolates tend to be more transparent.
Secondly, all products are NOT created equal – they differ significantly in strength, absorption, and elimination by the body and in the manner in which they are formulated. One should be mindful of the differences in doses available for each of these products, starting at a low or moderate dose and increasing as needed in order to find the lowest dose that provides the desired relief. In this way, one can individualize usage to maximize effectiveness while minimizing risk – a proper goal for the use of all medicinals.
Transparency: Receptra Naturals’ website has a database where you can look up lab reports for their products. The first time we checked, we got some 404 errors for a couple of the lab reports, but these glitches seem to have been fixed since then. We were able to see third-party lab reports for all their tinctures (though, apparently not for their topicals). 
It’s important to know that there is no “best” brand or product for everyone. The best CBD oil is the one that works well for you. Each person has a unique endocannabinoid system, body chemistry, and severity of the condition. A brand or product that works well for one person with a specific situation may not work for you at all. This reality is understandably frustrating for many of those who are new to CBD oil. 

Medterra prides itself on offering what it terms “true seed-to-sale purchases,” with the hemp crop used for its CBD oil cultivated and extracted to the exacting standards demanded by the Kentucky Department of Agriculture. Potential buyers may be encouraged, too, to know that “quality, consistency and safety are… top priorities” at Medterra, and to that end all of the raw materials the company uses are independently lab tested. Plus, those who decide to take the plunge and order from the provider’s site can reap the benefits of its rewards program, with points given for Facebook shares, reviews and purchases. Among the products on offer at Medterra are CBD oil tinctures, capsules and pain-alleviating cream, all of which fall under a money-back pledge if not deemed to be to customers’ satisfaction.
Kat’s Naturals not only takes the quality of its products seriously, but it also ensures that their contents are produced in a way that’s as environmentally friendly as possible. The essential oils in its best-selling Heal CBD Hemp Oil, for example, are harvested in a sustainable manner, while the hemp that goes into its range more generally is completely organically grown. And in a customer-friendly move, Kat’s Naturals provides CBD oil blends specifically tailored to users’ needs, whether they want to boost metabolism, get a good night’s rest or simply feel freer from muscle pain. Perhaps the most innovative Kat’s Naturals product, though, is its CBD-containing capsaicin cream. This topical owes its heat in part to a component commonly found within chili peppers, and the company’s website claims that it also helps give respite to neuropathy sufferers and those with Raynaud syndrome.
Cannabidiol, or CBD for short, is a phyto-cannabinoid found in cannabis plants. However, it does not cause the same psychoactive effects as other naturally occurring cannabinoids (such as tetrahydrocannabinol, or THC). CBD induces feelings of sleepiness and tranquility, making it suitable for insomnia and other sleep disorders; CBD can be used to alleviate symptoms of epilepsy, diabetes, and anxiety disorders, as well. Legality is an issue for some; all 50 states have laws governing the sale, possession, and use of CBD, and they vary significantly (see the table below for a full analysis).
Unlike other CBD oils, PureKana really does excel in CBD oil extractions due to their unique CO2 extraction process which provides a near 99% pure CBD oil. PureKana Natural CBD Oil is an unflavored, dietary and nutritional supplement for increased health and vitality. It is extremely effective in helping to treat chronic pain, support recovery from exercise-induced inflammation, swelling, management of normal, everyday stresses, and to help promote healthy sleep cycles.
A newcomer to our CBD oils ranking, RE: Botanicals is no stranger to hemp. Founded by John Roulac, a long-time hemp advocate and founder of the organic superfoods brand Nutiva, RE: Botanicals is one of the only CBD brands to earn the USDA organic seal. They deserve a shout-out for prioritizing regenerative agriculture, while keeping prices reasonable.   
CO2 extraction is one of the most common ways CBD is extracted from the hemp or cannabis plants. This method uses expensive equipment that adjusts temperature and pressure to extract the cannabinoids from the plant material, without damaging them. The other common method is to use solvents like ethanol or butane to extract the plant material. These solvents have to be burned off the final product which may damage the cannabinoids or terpenes in the process. There is also a risk that these solvents may not have burned off completely and could end up in your end product.
The main reason we like Kat’s Naturals CBD oils are because they use hempseed oil to infuse 1,500 mg of CBD isolate. While the hempseed itself doesn’t contain any actual CBD, it is chock-full of phytonutrients, plant protein, and other nutritious compounds. The only reason other companies use coconut or MCT oil to infuse the CBD instead of hempseed oil, is because hempseed is lower in saturated fat so it doesn’t have as great a bioavailability. In other words, taking a CBD oil infused in MCT oil will allow more of the active compound to reach parts of the body that you need it to. For combining the natural therapeutic elements of CBD with the nutritional benefits of hempseed, however, Kat’s Naturals is a great product. I would recommend using it as a daily health supplement moreso than an actual therapy to treat any kind of condition or ailment.
Of course, though, they offer less potent oils than that, with a product lineup that ranges from 300 mg CBD per bottle to 4,000 mg. Naturally the 4,000 mg option is the most expensive (this is the one that provides the “bomb” 60 mg dose), as it currently sells for $299. For long-term pain and anxiety relief, though, it may be well worth it if it is effective for you and helps replace your regular meds.
NuLeaf only offers one concentration of CBD oil, 50 mg/ml, and the ingredients are as simple as it gets: USDA Certified organic hemp oil and full spectrum hemp extract. NuLeaf essentially has only one product. But this strategy allows them to keep their prices reasonable and offer bulk buying options—you can buy a bottle of NuLeaf CBD oil containing 240 mg total CBD all the way up to 4,850 mg.
CBD Essence is another brand we’ve had plenty of experience with over the past 18 months or so, and my partner particularly likes his 600 mg Medicinal Grade tincture for quickly easing her anxiety. I haven’t tried them so much for may pain, but I do recall that a 30 mg dose was quite effective the last time I did take it. Also, the main reason they’re this high up on our list is because they’re a fair amount cheaper than Elixinol and PureKana. Their tinctures come in larger 2 oz bottles, but on a CBD-per-mg basis they’re about 20% less expensive than other top-quality brands.
Many expect easy answers and fast results. But as many who have achieved success can attest, there’s no substitute for doing your own research, accepting that there will be some trial and error, and having a good deal of patience to find what works well for you. The good news is that when you buy from one of the companies listed above, you know that you are getting a quality product from a reputable company. Many users have had success with each of these companies for a variety of conditions.
When it comes to bang for the buck, Lazarus Naturals is the industry leader. They’ve built a loyal customer base because of their low prices, high-quality products, and compassionate assistance program for those in need. In fact, they’ve been voted the Brand of the Year by members of the CBD Oil Users Group on Facebook for the last 3 years. We particularly like their dedication to posting third-party lab reports on their website by batch. Their 30-day money-back guarantee speaks to the confidence in the quality of their products which clearly makes them one of the best CBD oil brands on the market.
Even complete CBD novices should be thoroughly clued up on the compound and its effects after visiting the handy education section on Infinite CBD’s website. And for those who want to give CBD oil a try but don’t know where to start, there’s also a welcome chart breaking down the ways in which to consume the phytocannabinoid and the products most suited to each method. So, while Infinite CBD’s range may not be as extensive as those of other businesses of its kind, any such shortfall is more than made up for by the wealth of valuable information available to potential customers. What the company does offer, moreover, is good-value isolates – the strongest of which comes in at a powerful 5,000 mg – and capsules blended with caffeine and melatonin for day and night use, respectively. Meanwhile, people with muscle and joint problems might find relief from Infinite CBD’s “Freezing Point” cooling cream.
But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”

Like Premium Jane, Fab CBD is another newcomer to the industry, and they made this list simply because of how affordable they are. We received some samples quite awhile back, and while they weren’t the most potent products in the world, they absolutely did work and if you were to buy them from the online store they are about 15% cheaper than other top brands. ($79 for a 600 mg bottle compared to the average $95).
There are very few known adverse side effects of CBD. According to this study, CBD is “a major non-psychotropic constituent of cannabis, has multiple pharmacological actions, including anxiolytic, antipsychotic, antiemetic, and anti-inflammatory properties. But if you are looking for a high from CBD, you will not get that because CBD has no psychoactive effects. Do speak with your physician if you are concerned about drug interactions.
To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases.
The endocannabinoid system is spread throughout your brain and body, but primarily throughout your central nervous system. The interaction between cannabinoids and receptors is what produces effects like the regulation of mood, pain, appetite, inflammation, and memory. Plant-based cannabinoids, found in cannabis plants, also interact with the receptors (whimsically named CB1 and CB2) in the endocannabinoid system, and each affects your body in different ways. CBD and its infamous cousin THC are the 2 most well-known cannabinoids.
CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
Cutting-edge science has shown that the endocannabinoid system is dysregulated in nearly all pathological conditions. Thus, it stands to reason that “modulating endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans,” as Pal Pacher and George Kunos, scientists with the U.S. National Institutes of Health (NIH), suggested in a 2014 publication.

Dr. Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.

Transdermal Patches – Remember those patches people put on their bodies to quit smoking? These patches allowed for a slow release of nicotine over the course of a day? Well, the same idea exists with CBD patches. This is a convenient way to get CBD into your body and endocannabinoid system over the course of a day. CLICK HERE to see our favorite patch.
Elixinol has a wide range of products, but their CBD Tincture does the trick. It’s the cream of the crop regarding CBD oils and that reflects in its price. One dropper (1mg) from the 300 series contains 10mg of CBD. This allows you to get precise amounts of CBD and no guess work is required. Elixinol has received numerous awards for their products and extraction process.
In fact, not only will CBD not make you high, it has been proven to counteract the psychoactivity of THC. This property makes CBD highly useful as a medical treatment for a wide range of conditions. In terms of the CBD products you can buy, the amount of THC present varies from none at all in a pure CBD Isolate to a minimal amount (less than 0.3%) in a Full-Spectrum CBD product.
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